Jixun Zhan
Biological Engineering
Professor
Contact Information
Office Location: ENGR 402JPhone: 435-797-8774
Email: jixun.zhan@usu.edu
Additional Information:
Teaching Interests
Biological Engineering principles and techniques
Research Interests
Metabolic Engineering, Natural Product Biosynthesis, Biocatalysis, Drug Discovery
Awards
Outstanding Researcher, 2017
Department of Biological Engineering, Utah State University
Outstanding Researcher, 2015
Department of Biological Engineering, Utah State University
Outstanding Researcher, 2014
Department of Biological Engineering, Utah State University
Outstanding Researcher, 2013
Department of Biological Engineering, Utah State University
Outstanding Researcher, 2012
Department of Biological Engineering, Utah State University
Outstanding Undergraduate Faculty Adviser, 2012
Department of Biological Engineering, Utah State University
Outstanding Researcher, 2011
Department of Biological Engineering, Utah State University
Department of Defense Genetic Studies of Food Allergies Research Program (GSFARP) Concept Award, 2010
Department of Defense
NIH Academic Research Enhancement Award, 2010
NIH
American Heart Association Scientist Development Grant Award, 2009
American Heart Association
UCLA Chancellor’s Award for Postdoctoral Research Nominee, 2008
UCLA
American Heart Association postdoctoral fellowship, 2007
American Heart Association
First Prize National Award of Natural Science Research, 2005
Ministry of Education of China
East China University of Science and Technology Excellent Doctoral Dissertation Award, 2004
East China University of Science and Technology
East China University of Science and Technology DESANO Scholarship, 2002
East China University of Science and Technology
Tianjin University of Science and Technology Excellent Graduate Scholarship, 1999
Tianjin University
Tianjin University of Science and Technology Excellent Graduate Scholarship, 1998
Tianjin University
Nanchang University Outstanding Undergraduate Scholarship, 1996
Nanchang University
Nanchang University Outstanding Undergraduate Sholarship, 1995
Nanchang University
Publications | Books
- Zeng, J., Zhan, J., (2012). Preparation of halogenated molecules by a fungal flavin-dependent halogenase heterologously expressed in Escherichia coli: Practical Methods for Biocatalysis and Biotransformations, Volume 2. John Wiley & Sons
- Zhan, J., Gunatilaka, A., (2009). Chapter 8: Microbial transformation by Beauveria bassiana: Advances in Fungal Biotechnology. I.K. International
- Guo, D., Ye, M., Ning, L., Zhan, J., Guo, H., (2005). Chapter 17: Microbial transformation of natural products: Advances in Natural Product Chemistry. Chemical Industry Press
Publications | Book Chapters
An asterisk (*) at the end of a publication indicates that it has not been peer-reviewed.
Publications | Journal Articles
Academic Journal
- Chang, C.T, Takemoto, J.Y, Zhan, J., (2019). Natural Bioactive Compounds. Israel Journal of Chemistry, 59, 325-326. doi: https://doi.org/10.1002/ijch.201900050
- Yu, D., Xu, F., Zhang, S., Zhan, J., (2017). Decoding and reprogramming fungal iterative nonribosomal peptide synthetases. Nature Communications, 8, 15349.
- Fidan, O., Zhan, J., (2015). Recent advances in engineering yeast for pharmaceutical protein production. RSC Advances , 5, 86665–86674.
- Zhang, S., Wang, S., Zhan, J., (2015). Engineered biosynthesis of medicinally important plant natural products in microorganisms.. Current topics in medicinal chemistry
- Xu, F., Gage, D., Zhan, J., (2015). Efficient production of indigoidine in Escherichia coli.. Journal of industrial microbiology & biotechnology, 42:8, 1149-55.
- Liu, C., Yang, N., Song, Y., Wang, L., Zi, J., Zhang, S., Dunkin, D., Busse, P., Weir, D., Tversky, J., Miller, R., Goldfarb, J., Zhan, J., Li , X.M, (2015). Ganoderic acid C1 isolated from the anti-asthma formula, ASHMI™ suppresses TNF-α production by mouse macrophages and peripheral blood mononuclear cells from asthma patients.. International immunopharmacology, 27:2, 224-31.
- Kakule, T.B, Zhang, S., Zhan, J., Schmidt, E.W, (2015). Biosynthesis of the tetramic acids Sch210971 and Sch210972.. Organic letters, 17:10, 2295-7.
- Wang, S., Zhang, S., Xiao, A., Rasmussen, M., Skidmore, C., Zhan, J., (2015). Metabolic engineering of Escherichia coli for the biosynthesis of various phenylpropanoid derivatives.. Metabolic engineering, 29, 153-159.
- Zhang, S., Wang, S., Zhang, Q., Chang, C.W, Zhan, J., (2015). Three new fusidic acid derivatives and their antibacterial activity.. Bioorganic & medicinal chemistry letters, 25:9, 1920-1924.
- Napan, K.L, Zhang, S., Anderson, T., Takemoto, J.Y, Zhan, J., (2015). Three enzymes involved in the N-methylation and incorporation of the pradimicin sugar moieties. Biorganic and Medicinal Chemistry Letters, 26:6, 1288-1291. doi: doi.org/10.1016/j.bmcl.2015.01.043
- Sun, L., Zeng, J., Zhang, S., Gladwin, T., Zhan, J., (2015). Effects of exogenous nutrients on polyketide biosynthesis in Escherichia coli.. Applied microbiology and biotechnology, 99:2, 693-701.
- Yu, D., Xu, F., Shao, L., Zhan, J., (2014). A specific cytochrome P450 hydroxylase in herboxidiene biosynthesis. Bioorganic & Medicinal Chemistry Letters, 24:18, 4511–4514.
- Yang, N., Liu, C., Wang, J., Song, Y., Zhang, S., Zi, J., Zhan, J., Masilamani, M., Cox, A., Nowak-Wegrzyn, A., Sampson, H., Li, X., (2014). Berberine and limonin suppress IgE production by human B cell line and peripheral blood mononuclear cells from food-allergic patients. Annals of Allergy, Asthma & Immunology, 113:5, 556–564.e4.
- Xu, Y., Zhou, T., Zhang, S., Espinosa-Artiles, P., Wang, L., Zhang, W., Lin, M., Gunatilaka, A.L, Zhan, J., Molnar, I., (2014). Diversity-oriented combinatorial biosynthesis of benzenediol lactone scaffolds by subunit shuffling of fungal polyketide synthases. Proceedings of the National Academy of Sciences, U.S.A., 111:34, 12354–12359.
- Wang, S., Liu, G., Cai, N., Cheng, C., Ji, Y., Zhang, W., Sun, L., Zhan, J., Yuan, S., (2014). Efficient glycosylation of puerarin by an organic solvent-tolerant strain of Lysinibacillus fusiformis. Enzyme and Microbial Technology, 57, 42–47.
- Xu, Y., Zhou, T., Espinosa-Artiles, P., Tang, Y., Zhan, J., Molnar, I., (2014). Insights into the biosynthesis of the phytotoxic 12-membered resorcylic acid lactones resorcylide and lasiodiplodin from heterologous production in Saccharomyces cerevisiae. ACS Chemical Biology, 9:5, 1119–1127.
- Napan, K., Zhang, S., Morgan, W., Anderson, T., Takemoto, J.Y, Zhan, J., (2014). Synergistic actions of tailoring enzymes in pradimicin biosynthesis. ChemBioChem, 5:15, 2289–2296.
- Mei, J., Wang, L., Wang, S., Zhan, J., (2014). Synthesis of two new hydroxylated derivatives of spironolactone by microbial transformation. Bioorganic & Medicinal Chemistry Letters, 24:14, 3023–3025.
- Sun, L., Zeng, J., Zhang, S., Gladwin, T., Zhan, J., (2014). Effects of exogenous nutrients on polyketide biosynthesis in Escherichia coli.. Applied Microbiology and Biotechnology
- Yu, D., Xu, F., Zi, J., Wang, S., Gage, D., Zeng, J., Zhan, J., (2013). Engineered production of fungal anticancer cyclooligomer depsipeptides in Saccharomyces cerevisiae. Metabolic Engineering , 18, 60-68.
- Xu, Y., Zhou, T., Zhang, S., Xuan, L., Zhan, J., Molnar, I., (2013). Thioesterase domains of fungal nonreducing polyketide synthases act as decision gates during combinatorial biosynthesis. Journal of the American Chemical Society, 135:29, 10783-10791.
- Xu, Y., Zhou, T., Zhou, Z., Su, S., Roberts, S.A, Montfort, W.R, Zeng, J., Chen, M., Zhang, W., Lin, M., Zhan, J., Molnar, I., (2013). Rational reprogramming of fungal polyketide first ring cyclization. Proceedings of the National Academy of Sciences of the United States of America, 110:14, 5398-5403.
- Zeng, J., Lytle, A.K, Gage, D., Johnson, S.J, Zhan, J., (2013). Specific chlorination of isoquinolines by a fungal flavin-dependent halogenase. Bioorganic and Medicinal Chemistry Letters, 23:4, 1001-1003. doi: 10.1016/j.bmcl.2012.12.038
- Yu, D., Xu, F., Valiente, J., Wang, S., Zhan, J., (2013). An indigoidine biosynthetic gene cluster from Streptomyces chromofuscus ATCC 49982 contains an unusual IndB homologue. Journal of Industrial Microbiology and Biotechnology , 40:1, 159–168.
- Ma, B., Zeng, J., Shao, L., Zhan, J., (2013). Efficient bioconversion of quercetin into a novel glycoside by Streptomyces rimosus subsp. rimosus ATCC 10970. Journal of Bioscience and Bioengineering , 115:1, 24–26.
- Zi, J., Gladstone, S.G, Zhan, J., (2012). Specific 5-hydroxylation of piperlongumine by Beauveria bassiana ATCC 7159. Bioscience, Biotechnology, and Biochemistry , 76:8, 1565-1567.
- Zeng, J., Gage, D., Zhan, J., (2012). Production of a new pyridine N-oxide by bioconversion with Cunninghamella echinulata var. elegans. Journal of Bioscience and Bioengineering , 114:5, 497-499.
- Dimkpa, C., Zeng, J., McLean, J.E, Britt, D.W, Zhan, J., Anderson, A.J, (2012). Production of indole-3-acetic acid via the indole-3-acetamide pathway in the plant-beneficial bacterium, Pseudomonas chlororaphis O6 is inhibited by ZnO nanoparticles but enhanced by CuO nanoparticles. Applied and Environmental Microbiology/American Society for Microbiology, 78, 1404-1410. doi: doi:10.1128/AEM.07424-11
- Zeng, J., Decker, R., Zhan, J., (2012). Biochemical characterization of a type III polyketide biosynthetic gene cluster from Streptomyces toxytricini. Applied Biochemistry and Biotechnology , 166, 1020-1033.
- Dayu, Y., Fuchao, X., Jia, Z., Zhan, J., (2012). Type III polyketide synthases in natural product biosynthesis. IUBMB Life, 64:4, 285-295.
- Napan, K.L, Zeng, J., Takemoto, J.Y, Zhan, J., (2012). A key cytochrome P450 hydroxylase in pradimicin biosynthesis. Bioorganic and Medicinal Chemistry Letters , 22:1, 606-609. doi: doi:10.1016/j.bmcl.2011.10.075
- Shao, L., Zi, J., Zeng, J., Zhan, J., (2012). Identification of the herboxidiene biosynthetic gene cluster in Streptomyces chromofuscus ATCC 49982. Applied and Environmental Microbiology, 78:6, 2034-2038. doi: 10.1128/AEM.06904-11
- Zeng, J., Zhan, J., (2011). Characterization of a tryptophan 6-halogenase from Streptomyces toxytricini. Biotechnology Letters , 33, 1607–1613.
- Zeng, J., Valiente, J., Zhan, J., (2011). Generation of two new macrolactones through sequential biotransformation of dihydroresorcylide. Natural Product Communications , 6:2, 223-226.
- Sriastava, K., Yang, N., Chen, Y., Lopez Exposito, I., Song, Y., Goldfarb, J., Zhan, J., Sampson, H., Li, X., (2011). Efficacy, safety and immunological actions of butanol-extracted FAHF-2 on peanut anaphylaxis. Clinical & Experimental Allergy , 41:4, 582-591. doi: 10.1111/j.1365-2222.2010
- Zeng, J., Valiente, J., Zhan, J., (2011). Specific inhibition of the halogenase for radicicol biosynthesis by bromide at the transcription level in Pochonia chlamydosporia. Biotechnology Letters , 33, 333-338. doi: 10.1007/s10529-010-0427-1
- Zhang, J., Redman, N., Litke, A.P, Zeng, J., Zhan, J., Chan, K.Y, Chang, C.T, (2011). Synthesis and antibacterial activity study of a novel class of cationic anthraquinone analogs. Bioorganic & Medicinal Chemistry , 19, 498-503. doi: 10.1016/j.bmc.2010.11.001
- Zeng, J., Zhan, J., (2010). A novel fungal flavin-dependent halogenase for natural product biosynthesis. ChemBioChem, 11:15, 2119-2123.
- Zhan, J., Wijeratne, E.K, Gunatilaka, A.L, (2010). Structure determination of two new monocillin I derivatives. Natural Product Communications , 5:5, 801-804.
- Yu, D., Zeng, J., Chen, D., Zhan, J., (2010). Characterization and reconstitution of a new fungal type III polyketide synthase from Aspergillus oryzae. Enzyme and Microbial Technology , 46:7, 575-580.
- Zeng, J., Yang, N., Li, X., Shami, P.J, Zhan, J., (2010). 4'-O-Methylglycosylation of curcumin by Beauveria bassiana. Natural Product Communications , 5:1, 77-80.
- Zhan, J., (2009). Biosynthesis of bacterial aromatic polyketides. Current Topics in Medicinal Chemistry , 9, 1598-1610.
- Wang, P., Zhang, W., Zhan, J., Tang, Y., (2009). Identification of OxyE as an ancillary oxygenase during tetracycline biosynthesis. ChemBioChem , 10, 1544-1550.
- Zhan, J., Qiao, K., Tang, Y., (2009). Investigation of tailoring modifications in pradimicin biosynthesis. ChemBioChem, 10, 1447-1452.
- Zhou, H., Zhan, J., Watanabe, K., Xie, X., Tang, Y., (2008). A new class of polyketide macrolactone synthase from filamentous fungus Gibberella zeae. Proceedings of the National Academy of Sciences, U.S.A. , 105:17, 6249-6254.
- Zhang, W., Watanabe, K., Cai, X., Jung, M.E, Tang, Y., Zhan, J., (2008). Identifying the minimal enzymes required for anhydrotetracycline biosynthesis. Journal of the American Chemical Society , 130:19, 6068-6069.
- Zhan, J., Gunatilaka, A., (2008). Microbial metabolism of 1-aminoanthracene by Beauveria bassiana. Bioorganic & Medicinal Chemistry , 16:9, 5085-5089.
- Zhan, J., Watanabe, K., Tang, Y., (2008). Pradimicin A biosynthesis: Synergistic actions of monooxygenase and cyclases in polyketide biosynthesis. ChemBioChem, 9, 1710-1715.
- Ma, S.M, Zhan, J., Xie, X., Watanabe, K., Tang, Y., Zhang, W., (2008). Redirecting the cyclization steps of fungal polyketide synthase. Journal of the American Chemical Society , 130, 38-39.
- Zhang, W., Wilke, B.I, Zhan, J., Watanabe, K., Boddy, C.N, Tang, Y., (2007). A new mechanism for benzopyrone formation in aromatic polyketide biosynthesis. Journal of the American Chemical Society , 129, 9304-9305.
- Zhan, J., Gunaherath, G., Wijeratne, E., Gunatilaka, A., (2007). Asperpyrone D and other metabolites of the plant-associated fungal strain Aspergillus tubingensis. Phytochemistry, 68:3, 368-372.
- Xu, Y., Zhan, J., Wijeratne, E., Burns, A.M, Gunatilaka, A., Molnar, I., (2007). Cytotoxic and anti-haptotactic beauvericin analogs from precursor-directed biosynthesis with the insect pathogen Beauveria bassiana ATCC7159. Journal of Natural Products , 70:9, 1467-1471.
- Ma, S.M, Zhan, J., Watanabe, K., Xie, X., Zhang, W., Wang, C.C, Tang, Y., (2007). Enzymatic synthesis of novel polyketides using PKS4 from Gibberella fujikuroi. Journal of the American Chemical Society , 129:35, 10642-10643.
- Zhan, J., Burns, A.M, Liu, M.X, Faeth, S.H, Gunatilaka, A., (2007). Search for cell motility and angiogenesis inhibitors with potential anticancer activity: beauvericin and other constituents of two endophytic strains of Fusarium oxysporum. Journal of Natural Products , 70:2, 227-232.
- Zhang, H., Zhan, J., Su, K., Zhang, Y., (2006). A kind of potential food additive produced by Streptomyces coelicolor: characteristics of blue pigment and identification of a novel compound, -actinorhodin. Food Chemistry , 95, 186-192.
- Zhan, J., Guo, H., Ning, L., Zhang, Y., Guo, D., (2006). Efficient preparation of derivatives of resibufogenin using microbial catalytic technique. . Planta Medica , 72, 346-350.
- Zhan, J., Gunatilaka, A., (2006). Microbial transformation of amino- and hydroxyanthraquinones by Beauveria bassiana ATCC 7159. . Journal of Natural Products, 69:10, 1525-1527.
- Zhan, J., Gunatilaka, A., (2006). Selective 4'-O-methyl-glycosylation of the pentahydroxy-flavonoid quercetin by Beauveria bassiana ATCC 7159. Biocatalysis and Biotransformation , 24:5, 396-399.
- Zhan, J., Gunatilaka, A., (2005). Microbial transformation of curvularin. Journal of Natural Products, 68, 1271-1273.
- Zhan, J., Wijeratne, E., Seliga, C., Zhang, J., Pierson, E.E, Pierson, L.S, VanEtten, H.D, Gunatilaka, A., (2004). A new anthraquinone and cytotoxic curvularins of a Penicillium sp. from the Rhizosphere of Fallugia paradoxa of the Sonoran Desert. Journal of Antibiotics , 57, 341-344.
- He, J., Wijeratne, E., Bashyal, B.P, Zhan, J., Seliga, C.S, Liu, M.X, Pierson, E.E, Pierson, III, L.S, Vanetten, H.D, Gunatilaka, A., (2004). Cytotoxic and other constituents of Aspergillus inhabiting the rhizosphere of Sonoran desert plants. . Journal of Natural Products , 67, 1985-1991.
- Zhang, W., Ye, M., Zhan, J., Chen, Y., Guo, D., (2004). Microbial glycosylation of four free anthraquinones by Absidia coerulea. Biotechnology Letters , 26, 127-131.
- Ye, M., Ning, L., Zhan, J., Guo, H., Guo, D., (2004). Progress in biotransformation of triptolides and bufadienolides. . Journal of Peking University, Health sciences , 36:1, 82-89.
- Han, J., Dai, J., Cui, Y., Zhan, J., Guo, H., Guo, D., (2003). Biotransformation of artemisinin by Catharanthus roseus and Gingo biloba cell suspension cultures. Chinese Traditional and Herbal Drugs , 34:2, 166-168.
- Ye, M., Ning, L., Zhan, J., Guo, H., Guo, D., (2003). Biotransformation of cinobufagin by cell suspension cultures of Catharanthus roseus and Platycodon grandiflorum. Journal of Molecular Catalysis B: Enzymatic , 22, 89-95.
- Zhang, W., Zhan, J., Chen, Y., Guo, D., (2003). Biotransformation of three anthraquinones by Mucor spinosus. Chinese Journal of Natural Medicines , 1:4, 219-223.
- Ning, L., Zhan, J., Qu, G., Zhong, L., Guo, H., Bi, K., Guo, D., (2003). Biotransformation of triptolide by Cunninghamella blakesleana. Tetrahedron, 59, 4209-4213.
- Zhan, J., Zhang, Y., Liu, W., Guo, H., Guo, D., (2003). Directional modifications of resibufogenin by Mucor subtilissimus and Pseudomonas aeruginosa. Biocatalysis and Biotransformation , 21:3, 141-143.
- Zhan, J., Zhang, Y., Ning, L., Ye, M., Guo, H., Guo, D., (2003). Microbial transformation of paclitaxel by Pseudomonas aeruginosa AS 1.860. Chinese Journal of Applied Environmental Biology , 9:4, 429-432.
- Zhan, J., Zhong, J., Dai, J., Guo, H., Zhu, W., Zhang, Y., Guo, D., (2003). Microbial transformations of sinenxan A, a constituent of callus culture of Taxus. Acta Pharmaceutica Sinica , 38:7, 555-558.
- Zhan, J., Wei, Q., Shan, C., Han, J., Zhang, Y., Guo, D., (2003). Studies on in vitro antimalarial activities of several biotransformation products of artemisinin. China Tropical Medicine , 3:1, 17-18.
- Zhan, J., Wei, Q., Shan, C., Han, J., Zhang, Y., Guo, D., (2003). Studies on in vitro antimalarial activities of several biotransformation products of artemisinin. China Tropical Medicine , 3:1, 17-18.
- Zhan, J., Liu, T., Wang, D., Xia, L., Ding, Y., (2003). Studies on properties and application of xylanase produced by Aspergillus niger S13. Journal of Beijing Technology and Business University (Natural Science Edition) , 21:2, 4-6.
- Zhan, J., Guo, H., Han, J., Zhang, Y., Guo, D., (2002). Biotransformation of artemisinin by Rhizopus chinensis and Cunninghamella elegans. Chinese Traditional and Herbal Drugs , 33, 869-872.
- Zhan, J., Zhang, Y., Guo, H., Han, J., Ning, L., Guo, D., (2002). Microbial metabolism of artemisinin by Mucor polymorphosporus and Aspergillus niger. Journal of Natural Products , 65, 1693-1695.
- Zhan, J., Guo, H., Dai, J., Zhang, Y., Guo, D., (2002). Microbial transformation of artemisinin by Cunninghamella echinulata and Aspergillus niger. Tetrahedron Letters , 43, 4519-4521.
- Zhan, J., Liu, T., Wang, D., Xia, L., Ding, Y., (2002). Studies on liquid fermentation of Aspergillus niger S13 producing xylanase. Journal of Beijing Technology and Business University (Natural Science Edition, 20:4, 14-17.
- Zhan, J., Guo, H., Dai, J., Zhang, Y., Guo, D., (2001). Biotransformation of gastrodin by Mucor spinosus. Journal of Chinese Pharmaceutical Sciences , 10, 187-189.
Professional Journal
- Zi, J., Valiente, J., Zeng, J., Zhan, J., (2011). Metabolism of quercetin by Cunninghamella elegans ATCC 9245. Journal of Bioscience and Bioengineering , 112:4, 360–362.
An asterisk (*) at the end of a publication indicates that it has not been peer-reviewed.
Publications | Other
An asterisk (*) at the end of a publication indicates that it has not been peer-reviewed.